Researchers in Edinburgh have presented a quantitative, statistics-based approach to organelle proteonomics, the study of proteins, according to Genome Web.
The paper, "Proteomics of a fuzzy organelle: interphase chromatin," published on the 17, discusses methods for looking at chromatin, in context, without separating the parts.
Chromatin is the organelle comprised of DNA, histone proteins, and cofactors present in the nucleus of a cell.
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| This image from the Molecular Expressions Cell Biology and Microscopy site shows chromatin in its tangled form within the nucleus and stretched out and isolated. |
The paper discusses methods to look at not just the DNA, which is often isolated for sequencing studies, but to examine the complex itself and how the components interact with one another.
This may be another step to understanding the complex functionality of chromatin, and may set an example for other studies, looking at DNA in context, as a 3-D structure with a function dependent on interactions, rather than as a one dimensional piece of isolated information.
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